首页 | 本学科首页   官方微博 | 高级检索  
     


Age-Related Changes in the DNA and RNA Content of the Brain in Spontaneously Hypertensive Rats
Authors:Hiroshi Nakane  Tatsuo Nakahara  Hiroshi Yao  Hiroaki Ooboshi  Setsuro Ibayashi  Hideyuki Uchimura  Masatoshi Fujishima
Affiliation:(1) Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan;(2) Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, Japan;(3) Department of Chemistry, Faculty of Science, Kyushu University, Japan
Abstract:To elucidate the effects of aging accompanied with hypertension on brain nucleic acid, we measured both the DNA and RNA contents of six specific brain regions in adult (5–6 months old) and aged (18–22 months old) female spontaneously hypertensive rats (SHRs). Although no statistical difference was observed in the RNA content, the DNA content did tend to increase in the hippocampal CA1 of aged SHR (4.24 ± 0.55 ng/mgrg protein, mean ± SD, n = 6) in comparison to that of adult SHR (3.21 ± 0.71 ng/mgrg protein, n = 4). Hence, aged SHRs showed a significant decrease in the RNA to DNA ratio in the CA1 subfield of the hippocampus (3.79 ± 0.61) compared to adult SHR (5.27 ± 0.81). On the other hand, no other regions, except for the dorsolateral region of the striatum, showed any difference in the RNA/DNA ratio between aged and adult SHR. We therefore conclude that subtle changes in the nucleic acid occur in vulnerable regions of the brain in aged SHRs.
Keywords:Aging  DNA  RNA  brain  SHR  HPLC
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号