Piroxicam, a structurally novel anti-inflammatory compound. Mode of prostaglandin synthesis inhibition |
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Authors: | T J Carty J S Stevens J G Lombardino M J Parry M J Randall |
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Abstract: | Piroxicam is a potent inhibitor of prostaglandin biosynthesis. Experiments utilizing cell culture and microsomes derived from various sources have demonstrated that piroxicam is a selective inhibitor of the cyclooxygenase step of arachidonic acid metabolism. Little blocking activity is observed at the phospholipase, thromboxane or prostacyclin synthetase, and arachidonic acid lipoxygenase steps. |
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