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Nitric oxide inhibits proliferation but increases life-span of T lymphocytes in tumour-bearing rats |
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| Authors: | Danièle Reisser Patricia Lagadec Laurent Arnould Nathalie Onier Véronique Maupoil Dominique Pinard Jean-François Jeannin |
| Affiliation: | Ecole Pratique des Hautes Etudes, Cancer Immunotherapy Research Laboratory, Faculty of Medicine, 7 Bd. Jeanne d’Arc, 21033, Dijon Cedex, France e-mail: jfjeanni@u-bourgogne.fr Tel. and Fax number: +3 33 80 65 39 30, FR Anatomo-Pathology Laboratory, Centre Georges-Fran?ois Leclerc, Dijon, France, FR Experimental Cardiovascular Physiopathology and Pharmacology Laboratory, Faculty of Medicine, Dijon, France, FR |
| Abstract: | Nitric oxide (NO) has been shown to inhibit the proliferation of lymphocytes. However, in tumour-bearing rats treated with the immunomodulator OM 163, the regressing nodules were heavily infiltrated by T lymphocytes, although they contained high levels of NO. We show here that NO, while inhibiting the proliferation of lymphocytes, increased their life-span, pointing to the ambivalence of this molecule in the course of tumour growth and regression. Received: 16 October 1997 / Accepted: 8 January 1998 |
| Keywords: | Nitric oxide T lymphocytes Immunotherapy OM 163 |
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