ACTH 1-24-induced potentiation of norepinephrine contractile responses in aortic strips from spontaneously hypertensive (SH) and normotensive (WKY) rats |
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Authors: | R A Vergona F L Strand M R Cohen |
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Institution: | 1. Hoffmann-La Roche Inc., Department of Pharmacology, Nutley, NJ 07110 USA;2. Biology Department, New York University, Washington Square, New York, NY USA |
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Abstract: | Norepinephrine (NE)-induced contractile responses were less in aortic strips from SH compared to WKY rats. ACTH 1-24 potentiated NE responses in both SH and WKY aortic strips. This effect was more potent in SH aortic strips. NE-induced contractions in SH aortic strips were less sensitive to changes in external Ca2+ levels than were those of WKY aortic strips. ACTH 1-24 did not potentiate NE responses under low external Ca2+ conditions in SH aortic strips or under high external Ca2+ conditions in WKY aortic strips. The greater sensitivity of NE responses following ACTH 1-24 in SH aortic strips may imply that this peptide is modulating a mechanism related to an impaired contractility and that Ca2+ plays a key role in the observed effects. |
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Keywords: | ACTH Aortic strip Calcium Contractility Norepinephrine Spontaneous hypertension |
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