| 大鼠脾气虚结合胃溃疡模型中结肠 5-羟色胺及其受体的变化 |
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| 引用本文： | 赵素贤,王秀琴,杜鹃,曾小蓓,李宝红,孙海梅. 大鼠脾气虚结合胃溃疡模型中结肠 5-羟色胺及其受体的变化[J]. 中国组织化学与细胞化学杂志, 2006, 15(5): 499-503 |
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| 作者姓名： | 赵素贤 王秀琴 杜鹃 曾小蓓 李宝红 孙海梅 |
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| 作者单位： | 1. 军事医学科学院,北京,100850
2. 首都医科大学组织胚胎学教研室,北京,100069 |
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| 基金项目： | 北京市中国药局资助项目 |
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| 摘 要： | 目的探讨脾气虚胃溃疡证病结合模型结肠中5-羟色胺及其受体的变化,及加味四君子汤治疗脾虚证的机理。方法免疫组织化学染色和图像分析技术。结果脾气虚合并胃溃疡模型中结肠5-羟色胺及其受体阳性反应产物的含量均增加,经过加味四君子汤治疗后,上述指标的变化降低,接近对照组。结论大鼠脾气虚胃溃疡模型中结肠组织及其受体含量的增高可导致消化系统功能紊乱,可能是脾气虚胃溃疡的一种重要病因或病机之一,加味四君子汤能通过纠正这些变化而发挥治疗作用。
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| 关 键 词： | 5-羟色胺 5-羟色胺受体 脾虚胃溃疡 免疫组织化学 四君子汤 |
| 收稿时间： | 2005-12-30 |
| 修稿时间： | 2006-01-25 |
CHANGES OF 5-HT AND ITS REPTOR IN RAT COLON TISSUE OF SPLEEN-DEFICIENCY COMBINED WITH GASTRIC ULCER |
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| Zhao Suxian,Wang Xiuqin,Du Juan,Zeng Xiaobei,Li Baohong,Sun Haimei. CHANGES OF 5-HT AND ITS REPTOR IN RAT COLON TISSUE OF SPLEEN-DEFICIENCY COMBINED WITH GASTRIC ULCER[J]. Chinese Journal of Histochemistry and Cytochemistry, 2006, 15(5): 499-503 |
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| Authors: | Zhao Suxian Wang Xiuqin Du Juan Zeng Xiaobei Li Baohong Sun Haimei |
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| Affiliation: | Department of Histology and Embryology, Capital University of Medical Sciences, Beijing 100069;1 Academy of Militalry Medical Sciences, Beijing 100850, China |
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| Abstract: | Objective To study Changes of 5-HT receptor in colon of rat with spleen deficiency combined with gastric ulcer and the therapic mechanism of Sijunzi decoction.Methods Immunohistochemistry technique and image analysis were used.Results Immunohistochemical study showed that the level of 5-HT and 5-HT receptor in the colon was higher.After treatment with Sijunzi decoction,all the changes were reversed.Conclusion The increase in the number of 5-HT and 5-HT receptors in colon can lead to the disturbance of the function of the digestive system,which may be an important factor in the pathogenesis or pathology of spleen deficiency combined with gastric ulcer.Sijunzi decoction may play therapic role by correcting above changes. |
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| Keywords: | 5-Hydroxytryptamine 5-Hydroxytryptamine receptor Spleen deficiency syndrome combined with gastric ulcer Immunohistochemistry Sijunzi decoction |
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