Recognition of D-homoannulation by proton and carbon NMR spectra |
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| Authors: | L L Smith E L Ezell |
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| Institution: | Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550. |
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| Abstract: | One-and two dimensional proton and carbon NMR spectra of the D-homoannulated rearrangement product of triamcinolone (9 alpha-fluoro-11 beta,16 alpha,17 alpha, 21-tetrahydroxy-pregna-1,4-diene-3,20-dione) establish its structure as that of 9 alpha-fluoro-11 beta,16 alpha,17 alpha-trihydroxy-17 beta-hydroxy-methyl-D-homoandrosta-1,4-diene-3,17 alpha-dione. These methods accord ready recognition of D-homoannulation of C21-17-hydroxy-20-ketosteroids. |
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