Evaluation of <Emphasis Type="BoldItalic">Sterculia foetida</Emphasis> Gum as Controlled Release Excipient |
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Authors: | Amit Ashok Chivate Sushilkumar Sharatchandra Poddar Shajahan Abdul Gaurav Savant |
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Institution: | (1) Department of Pharmaceutics, Principal K. M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai, 400005, India;(2) 103, Indu Apt, Friends Colony, Bhandup (East), Mumbai, 400042, Maharashtra, India |
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Abstract: | The purpose of the research was to evaluate Sterculia foetida gum as a hydrophilic matrix polymer for controlled release preparation. For evaluation as a matrix polymer; characterization
of Sterculia foetida gum was done. Viscosity, pH, scanning electronmicrographs were determined. Different formulation aspects considered were:
gum concentration (10–40%), particle size (75–420 μm) and type of fillers and those for dissolution studies; pH, and stirring
speed were considered. Tablets prepared with Sterculia foetida gum were compared with tablets prepared with Hydroxymethylcellulose K15M. The release rate profiles were evaluated through
different kinetic equations: zero-order, first-order, Higuchi, Hixon-Crowell and Korsemeyer and Peppas models. The scanning
electronmicrographs showed that the gum particles were somewhat triangular. The viscosity of 1% solution was found to be 950
centipoise and pH was in range of 4–5. Suitable matrix release profile could be obtained at 40% gum concentration. Higher
sustained release profiles were obtained for Sterculia foetida gum particles in size range of 76–125 μm. Notable influences were obtained for type of fillers. Significant differences were
also observed with rotational speed and dissolution media pH. The in vitro release profiles indicated that tablets prepared from Sterculia foetida gum had higher retarding capacity than tablets prepared with Hydroxymethylcellulose K15M prepared tablets. The differential
scanning calorimetry results indicated that there are no interactions of Sterculia foetida gum with diltiazem hydrochloride. It was observed that release of the drug followed through surface erosion and anomalous
diffusion. Thus, it could be concluded that Sterculia foetida gum could be used a controlled release matrix polymer. |
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Keywords: | controlled-release natural gum Sterculia foetida gum |
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