Secondary metabolites of the fungusMonascus: A review |
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| Authors: | P Jůzlová L Martínková V Křen |
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| Affiliation: | (1) Department of Fermentation Chemistry and Bioengineering, Institute of Chemical Technology, 166 28 Prague 6, Czech Republic;(2) Laboratory of Biotransformation, Department of Biogenesis and Biotechnology of Natural Products, Institute of Microbiology, Czech Academy of Sciences, 142 20 Prague 4, Czech Republic |
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| Abstract: | This review deals with polyketides produced by the filamentous fungusMonascus which include: 1) a group of yellow, orange and red pigments, 2) a group of antihypercholesterolemic agents including mevinolin and related compounds and 3) the newly discovered metabolite ankalactone. Biosynthesis, methods of production, isolation and biological activities of these secondary metabolites are discussed. |
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| Keywords: | Monascus pigments rubropunctatin monascorubrin rubropunctamine monascorubramine ankaflavin monascin mevinolin monacolin lovastatin ankalactone |
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