H-2 and Background influences on tissue grafts across the H-Y barrier |
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Authors: | Roberta DeMott-Friberg Theodore F Beals Jane S Schultz |
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Institution: | 1. Veterans Administration Medical Center, 48105, Ann Arbor, Michigan 2. Departments of Genetics and Pathology, University of Michigan, 48109, Ann Arbor, Michigan
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Abstract: | Male liver was grafted to kidney beds in syngeneic female mice. Relative influences ofH-2 haplotype, genetic background or interaction ofH-2 haplotype with genetic background on anti-H-Y response were evaluated using 27 inbred strains carrying eightH-2 haplotypes of independent origin and three naturally occurring recombinants. Females ofH-2 b haplotype acutely rejected the male graft as is reported for other tissue graft systems. AnH-2 haplotype influence was found for all haplotypes studied, with a greater variation of immunologic response revealed by histological analysis of liver grafts than is demonstrated by skin grafts. Strains carryingH-2 k ,H-2 j andH-2 p haplotypes expressed the greatest range of immunological variability with responses ranging from graft proliferation to graft rejection. Strains carrying theH-2 d haplotype had the most consistent responses with little reaction to the graft. The strong immune response by SJL/J (H-2 s ) female mice to the H-Y antigen is not typical of otherH-2 s strains, but is compatible with the reported hyperresponsiveness of this strain to alloantigens. |
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