|
|||||
|
|
Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells |
|
| Authors: | Khromykh Ludmila M Kulikova Natalia L Anfalova Tatiana V Muranova Tatiana A Abramov Vyacheslav M Vasiliev Anatoliy M Khlebnikov Valentin S Kazansky Dmitriy B |
| Institution: | a Laboratory of Regulatory Mechanisms in Immunity, Carcinogenesis Institute State Institution Russian N.N. Blokhin Cancer Research Center Russian Academy of Medical Sciences, Kashirskoe shosse 24, 115478 Moscow, Russia b Department of Biochemistry of Immunity and Biodefence, Open Joint-Stock Company Institute of Engineering Immunology, Russia c Laboratory of protein chemistry, Branch of Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russia |
| Abstract: | Supernatant obtained from high dose hydrocortisone resistant thymocytes can induce migration of the bone marrow cell precursors to the periphery. This biological activity depends on the presence of the 18 kDa protein, whose amino acid sequence fits with the sequence of the secretory form of murine cyclophilin A (SP-18). Cyclophilin A isolated from the supernatant of the cortisone-resistant thymoma EL-4 shows its characteristic functional features as it demonstrates isomerase activity and binds with cyclosporine A. The cyclophilin A obtained manifests chemotactic activity that regulates migration of bone marrow cell precursors of neutrophils, T-, B- and dendritic cells. |
| Keywords: | Cyclophilin A Thymocytes Chemotaxis Bone marrow precursors |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |