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Identification and in vitro anti-esophageal cancer activity of a series of halogenated monoterpenes isolated from the South African seaweeds Plocamium suhrii and Plocamium cornutum |
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| Authors: | Antunes Edith M Afolayan Anthonia F Chiwakata Maynard T Fakee Jameel Knott Michael G Whibley Catherine E Hendricks Denver T Bolton John J Beukes Denzil R |
| Institution: | a Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa b Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, Private Bag X3, Observatory 7935, South Africa c Department of Botany, University of Cape Town, Rondebosch 7701, South Africa |
| Abstract: | Five known (1, 2, 4, 6 and 7) halogenated monoterpenes together with 1Z,3R∗,4S∗,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene (3) and (3R∗,4S∗)-3,4,6,7-tetrachloro-3,7-dimethyl-octen-1-ene (5) were isolated from the red macroalga Plocamium suhrii and their structures deduced from their spectroscopic data. The seven compounds from P. suhrii together with five related compounds from Plocamium cornutum have been evaluated for their cytotoxic effects on an esophageal cancer cell line (WHCO1). Compounds 1-6 showed greater cytotoxicity in this assay as compared to the known anticancer drug cisplatin. |
| Keywords: | Plocamium suhrii Plocamium cornutum Halogenated monoterpenes Cytotoxicity Esophageal cancer |
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