Lack of molecular relationships between lipid peroxidation and mitochondrial DNA single strand breaks in isolated rat hepatocytes and mitochondria |
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| Authors: | Scotti Claudia Iamele Luisa Alessandrini Andrea Vannini Vanio Cazzalini Ornella Lazzè Maria C Melli Raffaele Savio Monica Pizzala Roberto Stivala Lucia A Biglieri Silvia Tomasi Aldo Bianchi Livia |
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| Institution: | Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale, Università di Pavia, Piazza Botta 10, 27100 Pavia, Italy. claudia@manuzio.unipv.it |
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| Abstract: | We investigated the molecular relationships between lipid peroxidation and mitochondrial DNA (mtDNA) single strand breaks (ssb) in isolated rat hepatocytes and mitochondria exposed to tert-butylhydroperoxide (TBH). Our results show that mtDNA ssb induced by TBH are independent of lipid peroxidation and dependent on the presence of iron and of hydroxyl free radicals. These data contribute to the definition of the mechanisms whereby mtDNA ssb are induced and provide possible molecular targets for the prevention of this kind of damage in vivo. |
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