Cerebellar metabolism of phosphatidylethanolamine and its water-soluble precursors during bicuculline-induced convulsive seizures |
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Authors: | Ndok Marku Lanfranco Corazzi Gian Luigi Piccinin Giuseppe Arienti |
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Institution: | (1) Department of Biological Chemistry, The Medical School, University of Perugia, Via del Giochetto, 06100 Perugia, Italy;(2) Department of Neurology, Hospital of Perugia, Via dal Pozzo, 06100 Perugia, Italy |
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Abstract: | The incorporation of labeled ethanolamine into phosphatidylethanolamine (PE) and its water-soluble precursor, phosphoetanolamine and CDP-ethanolamine, is measured in rat cerebella during the course of bicuculline-induced convulsive seizures. The labeling of CDP-ethanolamine and phosphoethanolamine diminishes 6 min after the administration of both bicuculline and radioactive ethanolamine whereas that of PE is unaffected in these conditions. Time is very important to this effect; indeed, no differences of the labeling of PE water-soluble precursors can be found in rat cerebellum of normal and convulsing animals 12 min after the administration. The cerebellar pool of CDP-ethanolamine doubles after 6 min of convulsions, which means that unlabeled CDP-ethanolamine forms from a non-radioactive source, such as lipid, may be through the reversal of the ethanolamine phosphotransferase reaction. This effect disappears 12 min after the injection of the convulsant. |
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Keywords: | Phosphoethanolamine phosphatidylethanolamine bicuculline convulsions CDP-ethanolamine |
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