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Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen
Institution:1. Center for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;2. Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;3. Shiseido Global Innovation Center, Yokohama, Japan;4. Broad Institute of MIT and Harvard, Cambridge, MA, USA;1. Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA;2. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain;3. Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA;4. Departments of Cell Biology and Dermatology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA;1. Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland;2. Neuchâtel Platform of Analytical Chemistry, University of Neuchâtel, 2000 Neuchâtel, Switzerland;1. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;2. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119234, Russia;3. Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey;4. i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal;5. Aging and Aneuploidy Laboratory, IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal;6. Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA;7. Quantitative Medicine and Systems Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA;8. Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA;9. Broad Institute, Cambridge, MA, USA;1. Laboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA;1. School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China;2. Research Center for Brain Health, Pazhou Lab, Guangzhou 510330, China;3. School of Psychology, Shenzhen University, Shenzhen 518060, China;4. Research Center for Brain-Computer Interface, Pazhou Lab, Guangzhou 510330, China;5. School of Automation Science and Engineering, South China University of Technology, Guangzhou, 510640, China;1. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA;2. Department of Molecular and Cell Biology, University of California Berkeley, CA 94720, USA;3. Zealand Pharma A/S, Sydmarken 11, Soborg 2860, Denmark;4. QB3 Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley CA 94720, USA;5. Department of Chemistry, University of California, Berkeley, Berkeley CA 94720, USA;6. Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, Marburg 35037, Germany;7. Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley CA 94720, USA
Abstract:
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  • Keywords:senescent cell  cytomegalovirus  glycoprotein B  fibroblast  aging  skin  antiviral immunity
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