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Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
Institution:1. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;2. Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA;3. Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;4. Division of Biology, Kansas State University, Manhattan, KS, USA;5. Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA;6. Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;7. Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA;8. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;9. Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA;10. Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;11. Genetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA;12. Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;13. Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA;1. Division of Tumor Biology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands;1. Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA;1. Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA;2. Department of Systems Biology, Harvard Medical School, Boston, MA, USA;3. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;4. AGORA Cancer Research Center, Lausanne, Switzerland;5. Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands;6. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA;7. Service of Medical Oncology, Department of Oncology, CHUV, Lausanne, Switzerland;8. Department of Oncology, University of Lausanne, Lausanne, Switzerland;9. Ludwig Institute for Cancer Research, Lausanne, Switzerland;10. Department of Oncology, CHUV, Lausanne, Switzerland;11. Swiss Cancer Center Leman, Lausanne, Switzerland;1. State Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China;2. Changping Laboratory, Beijing 102206, China;3. Changping Laboratory Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China;4. MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China;5. National Institute of Biological Sciences, Beijing 102206, China;6. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, China;7. National Biomedical Imaging Center, Peking University, Beijing 100871, China;1. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA 02134, USA;2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;3. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA;4. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;5. Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;6. Cardiovascular Disease Initiative and Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;1. Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;3. Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;4. Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA;5. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;6. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;7. Program for Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;8. Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA;9. Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;10. Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA
Abstract:
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  • Keywords:melanoma  immune checkpoint inhibitor  aryl hydrocarbon receptor  indole-3-aldehyde  tryptophan  microbial AhR ligands  tumor microbiome  microbial-host crosstalk
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