Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants |
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| Authors: | Jakob Fay Deike Varoga Christoph J Wruck Bodo Kurz Mary B Goldring Thomas Pufe |
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| Affiliation: | (1) Department of Trauma Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 7, 24105 Kiel, Germany;(2) Department of Anatomy, Christian-Albrechts-University Kiel, Olshausenstrasse 40, 24098 Kiel, Germany;(3) Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, HIM-246, 4 Blackfan Circle, 02115-5713 Boston, MA, USA;(4) Hospital for Special Surgery, Caspary Research Building, Room 528, 535 E. 70th Street, 10021 New York, NY, USA |
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| Abstract: | Vascular endothelial growth factor (VEGF) promotes cartilage-degrading pathways, and there is evidence for the involvement of reactive oxygen species (ROS) in cartilage degeneration. However, a relationship between ROS and VEGF has not been reported. Here, we investigate whether the expression of VEGF is modulated by ROS. |
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