Mesenchymal stem cells: revisiting history, concepts, and assays |
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| Authors: | Bianco Paolo Robey Pamela Gehron Simmons Paul J |
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| Affiliation: | 1. Department of Experimental Medicine and Pathology, La Sapienza University, 00161 Rome, Italy;2. Biomedical Science Park San Raffaele, 00128 Rome, Italy;3. Craniofacial and Skeletal Diseases Branch, Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA;4. Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA |
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| Abstract: | The concept of mesenchymal stem cells has gained wide popularity. Despite the rapid growth of the field, uncertainties remain with respect to the defining characteristics of these cells, including their potency and self-renewal. These uncertainties are reflected in a growing tendency to question the very use of the term. This commentary revisits the experimental origin of the concept of the population(s) referred to as mesenchymal stem cells and the experimental framework required to assess their stemness and function. |
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