Conversion of Unprotected Amino-Link Oligonucleotides into Their Tetramethylguanidinium Derivatives |
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| Authors: | B. Greiner E. Uhlmann |
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| Affiliation: | Hoechst Marion Roussel , Chemical Research G 838, D-65926, Frankfurt a. M., Germany |
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| Abstract: | Abstract The preparation of tetramethylguanidinium oligodeoxynucleotide (ODN) derivatives by reaction of the corresponding aminoalkyl-ODN with the uronium salts HBTU, TBTU or HATU, respectively, is described. The binding affinity of the new tetramethylguanidinium ODN derivatives was determined. |
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