Synthesis of Fully Protected Nucleoside- Folic Acid Conjugated Phosphoramidites and Their Incorporation into Antisense Oligonuleotides |
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| Authors: | Balkrishen Bhat Guity Balow Andrei Guzaev P. Dan Cook Muthiah Manoharan |
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| Affiliation: | Department of Medicinal Chemistry , Isis Pharmaceuticals 2292 Faraday Avenue , Carlsbad, CA, 92008, USA |
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| Abstract: | Abstract A novel synthesis of the nucleoside-folic acid conjugates has been accomplished. This approach allowed us to synthesize several analogs, which were converted to phosphoramidites and successfully incorporated into therapeutically active antisense oligonucleotides. |
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