Visible Light Activatable Binary System of Oligonucleotide Conjugates for Nucleic Acids Modification |
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| Authors: | M. I. Dobrikov T. I. Gainutdinov V. V. Vlassov |
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| Affiliation: | Institute of Bioorganic Chemistry, Russian Academy of Sciences , 8, Lavrentiev Ave., Novosibirsk, 30090, Russia |
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| Abstract: | ![]()
Abstract A binary system of oligonucleotides conjugated to perfluoroarylazide and perylene for sequence-specific photomodification of nucleic acids has been developed. The system can be activated by visible light (450-580 nm), reacts 300000 times faster than azide in the absence of perylene and provides highly efficient (up to 99%) photomodification of target ssDNA. |
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