Nucleoside Modifications Affect the Structure and Stability of the Anticodon of tRNALys,3 |
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| Authors: | Darrell R Davis Philippe C Durant |
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| Institution: | Department of Medicinal Chemistry , University of Utah , Salt Lake City, Utah, 84112, USA |
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| Abstract: | Abstract NMR spectroscopy was used to determine the solution structures of RNA oligonucleotides comprising the anticodon domain of tRNALys,3. The structural effects of the pseudouridine modification at position 39 were investigated and are well correlated with changes in thermodynamic parameters. The loop conformation differs from that seen in tRNAPhe and provides an explanation of the critical role of modification in this tRNA. |
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