The Synthesis and Biological activity of a Highly Selective Adenosine A2a. Receptor Agonist |
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| Authors: | David R. Borcherding Nelsen L. Lentz Philip M. Weintraub Mark W. Dudley Roberta Secrest Philip R. Kastner |
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| Affiliation: | Inc., Rt. , 202-206, Bridgewater, NJ, 08807, USA |
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| Abstract: | ![]()
Abstract Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound 1 was shown to be the most selective A2a receptor agonist reported to date having an A1/A2 ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate. |
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