Ion channels in asthma |
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Authors: | Valverde Miguel A Cantero-Recasens Gerard Garcia-Elias Anna Jung Carole Carreras-Sureda Amado Vicente Rubén |
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Institution: | Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain. miguel.valverde@upf.edu |
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Abstract: | Ion channels are specialized transmembrane proteins that permit the passive flow of ions following their electrochemical gradients. In the airways, ion channels participate in the production of epithelium-based hydroelectrolytic secretions and in the control of intracellular Ca(2+) levels that will ultimately activate almost all lung cells, either resident or circulating. Thus, ion channels have been the center of many studies aiming to understand asthma pathophysiological mechanisms or to identify therapeutic targets for better control of the disease. In this minireview, we focus on molecular, genetic, and animal model studies associating ion channels with asthma. |
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Keywords: | Calcium Channels Chloride Channels Inflammation Potassium Channels TRP Channels Airways Asthma Capsaicin |
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