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The Role of RNA in Biological Phase Separations |
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| Authors: | Marta M Fay Paul J Anderson |
| Institution: | Division of Rheumatology, Immunology and Allergy, Brigham and Women''s Hospital, Boston, MA 02115, USA;Department of Medicine, Harvard Medical School, Boston, MA 02115, USA |
| Abstract: | Phase transitions that alter the physical state of ribonucleoprotein particles contribute to the spacial and temporal organization of the densely packed intracellular environment. This allows cells to organize biologically coupled processes as well as respond to environmental stimuli. RNA plays a key role in phase separation events that modulate various aspects of RNA metabolism. Here, we review the role that RNA plays in ribonucleoprotein phase separations. |
| Keywords: | RNA phase separation membraneless organelle dsDNA double-stranded DNA MLOs membrane-less organelles rRNA ribosomal RNA SGs stress granules LLPS liquid–liquid phase separation b-isox biotinylated isoxazole LCD low-complexity domain PTB polypyrimidine tract-binding protein ALS amyotrophic lateral sclerosis FTD frontotemporal dementia lncRNA long non-coding RNA snRNP small nuclear ribonucleoprotein snoRNAs small nucleolar RNAs scaRNAs Cajal body-specific RNAs rDNA ribosomal DNA FISH FRAP fluorescence recovery after photobleaching pol polymerase |
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