| 大鼠侧脑室注射精氨酸加压素对针刺镇痛的影响 |
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| 引用本文： | 宋朝佑,刘文彦.大鼠侧脑室注射精氨酸加压素对针刺镇痛的影响[J].中国应用生理学杂志,1991,7(1):26-30. |
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| 作者姓名： | 宋朝佑 刘文彦 |
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| 作者单位： | 第二军医大学神经生物学教研室，济宁医学院生理学教研室，第二军医大学神经生物学教研室，第二军医大学神经生物学教研室，第二军医大学神经生物学教研室 上海 200433，上海 200433，上海 200433，上海 200433 |
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| 摘 要： | 以钾离子透入法引起大鼠甩尾反应为指标,测定动物的痛阈。由侧脑室注射精氮酸加压素(AVP)后,大鼠痛阈升高33.6％～68.5％,针刺镇痛效应明显加强,痛阈提高202.4％～302.7％。脑室注射抗精氨酸加压素血清,动物痛阈虽无明显变化,但针刺镇痛效应明显削弱,痛阈仅增加41.6％～71.0％。注射抗β-内啡肽血清和抗强啡肽A血清并不阻断AVP增强针刺镇痛效应。本工作的结果提示,脑内AVP参与针刺镇痛,这种作用与脑内内源性β-内啡肽和强啡肽的关系不甚密切。
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| 关 键 词： | 精氨酸加压素 抗精氮酸加压素血清 痛阈 电针镇痛 |
THE EFFECT OF INTRAVENTRICULAR INJECTION OF ARGININE-VASOPRESSIN ON ACUPUNCTURE ANALGESIA IN RAT |
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| Song Chaoyou,Liu Wenyan,Yang Jun,Lin Baocheng,Wang Chenghai.THE EFFECT OF INTRAVENTRICULAR INJECTION OF ARGININE-VASOPRESSIN ON ACUPUNCTURE ANALGESIA IN RAT[J].Chinese Journal of Applied Physiology,1991,7(1):26-30. |
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| Authors: | Song Chaoyou Liu Wenyan Yang Jun Lin Baocheng Wang Chenghai |
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| Abstract: | The present study was designed to determine whether arginine-vasopressin (AVP) in brain was involved in EA analgesia or not and the mechanism of the action of AVP. The potassium ionophoresis-induced tail-flick was used as an index to measure the pain threshold in rats. Intraventricular injection of AVP(lOOng) not only raised the pain threshold (33.6% -68.5%), but also enhanced the EA analgesia (202. 4%-302.7%). Injection of anti-AVP serum could weaken the analgesic effect of EA significantly, but it could not change the pain threshold. Furthermore, it was also observed that injection of anti-beta-endorphin serum and anti-dynorphin A serum could not block the enhancement of EA analgesia induced by AVP. These results suggest that AVP in brain participates in the process of EA analgesia and this action of AVP is not closely related to the endogenous beta-endorphin and dynorphin in brain. |
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| Keywords: | arginine-vasopressin (AVP) anti-arginine-vasopressin serum pain threshold (PT) electroacupuncture (EA) analgesia |
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