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A lanostane aldehyde from Momordica charantia
Authors:Bella G Panlilio  Allan Patrick G Macabeo  Matthias Knorn  Paul Kohls  Pascal Richomme  Simeon Fogue Kouam  Dietmar Gehle  Karsten Krohn  Scott G Franzblau  Qingwen Zhang  Ma Alicia M Aguinaldo
Institution:1. Graduate School, University of Santo Tomas, Espana, Manila 1015, Philippines;2. Phytochemistry Laboratory, Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., Manila 1015, Philippines;3. Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany;4. Université d’ Angers, SONAS UPRES-EA 921, UFR des Sciences Pharmaceutiques et Ingéniere de la Santé, 16 Bd Daviers, F-49100 Angers, France;5. University of Paderborn, Department of Chemistry, Warburgerstr. 100, 33098 Paderborn, Germany;6. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, IL 60612-7231, USA;7. State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Tomás Pereira, Taipa, Macau;8. Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira, Taipa, Macau
Abstract:A new lanostane aldehyde, charantal (1), was isolated from the ethanolic leaf extract of Momordica charantia together with the known compound, 2,4-bis(2-phenylpropan-2-yl)phenol (2). The structure of compound 1 was elucidated by extensive 1D and 2D NMR and MS experiments. Compound 2 displayed a moderately strong antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC = 14 μg/mL) according to the MABA susceptibility assay.
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