Novel aminoalkaloids from European mistletoe (Viscum album L.) |
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Authors: | Bashar Amer Ole Johan Juvik Frédéric Dupont George W Francis Torgils Fossen |
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Institution: | 1. Department of Chemistry and Centre for Pharmacy, University of Bergen, Allégt. 41, N-5007 Bergen, Norway;2. Department of Botany, Faculty of Pharmacy, University of Lille 2, PO Box 83, 3 Rue du Professeur Laguesse, 59006 Lille Cedex, France |
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Abstract: | The European white-berry mistletoe (Viscum album L.) has remained an important medicinal plant for millennia. Preparations of the plant have found application in the treatment of cancer and the anticancer activity of mistletoe extracts has been ascribed to the presence of lectins, viscotoxins and alkaloids. However, the alkaloids of this species have hitherto remained unidentified because of their claimed extreme lability. Here we report on the isolation and characterisation of the novel aminoalkaloids 4,5,4′-trihydroxy-3,3′-iminodibenzoic acid (1) and 4,5,4′,5′-tetrahydroxy-3,3′-iminodibenzoic acid (2) from V. album L. The compounds define a novel group of aminoalkaloids and are the first novel alkaloids ever identified in any mistletoe species. The structures were established using a combination of several 2D NMR spectroscopic techniques and high resolution mass spectrometry. |
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