Expression of 14-3-3γ in patients with breast cancer: Correlation with clinicopathological features and prognosis |
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| Authors: | Yulan Song Zheng Yang Zunfu Ke Yunhong Yao Xinrong Hu Yanqin Sun Hongmei Li Jinbao Yin Chao Zeng |
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| Institution: | 1. Department of Pathology, Guang Dong Medical College, Dongguan 523808, China;2. Department of Pathology, The first affiliated hospital of Guang Dong Pharmaceutical University, Guangzhou, China;3. Department of Pathology, The first affiliated hospital of Sun Yat-sen University, Guangzhou, China;3. Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390;4. Department of Biophysics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390;5. Dallas Veterans Affairs Medical Center, Dallas, Texas 75216;1. Conway Institute, University College Dublin, Dublin, Ireland;2. School of Medicine and Medical Science, University College Dublin, Dublin, Ireland;3. Mass Spectrometry Resource, Conway Institute, University College Dublin, Dublin, Ireland;1. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China;2. Department of General Surgery, Shanghai Children’s Medical Center, Shanghai, China;1. Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;2. Università della Svizzera italiana, Lugano, Switzerland;3. Division of Cancer Sciences, University of Manchester, Manchester, UK;4. Translational Oncogenomics, Cancer Research UK Manchester Institute and Manchester Cancer Research Centre, Manchester, UK |
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| Abstract: | AimProtein 14-3-3γ is an important member of the 14-3-3 family that play important roles in the regulation of various cellular processes. The aim of the study is to investigate the association between 14-3-3γ expression and the clinicopathological features of patients with breast cancer.MethodsThe expression of 14-3-3γ was detected by Western blot in both foci of breast cancer and adjacent non-cancerous tissues. In addition, 14-3-3γ expression was analyzed by immunohistochemistry in 60 clinicopathologically characterized breast cancer cases. The association of 14-3-3γ expression with survival of the patients were analyzed.ResultsThe expression level of 14-3-3γ protein in breast cancer were significantly higher than that in non-cancerous mammary gland tissues. Moreover, high expression of 14-3-3γ correlated with tumor size and tumor grade (all P < 0.05). Patients with high 14-3-3γ expression had worse overall survival rate than that with low expression (P < 0.05). Furthermore, multivariate analysis showed that 14-3-3γ expression was an independent predictor of overall survival (HR, 0.196; 95%CI, 0.043–0.892; P = 0.035).ConclusionsOur data suggest for the first time that the increased expression of 14-3-3γ in breast cancer is associated significantly with tumor progression and poor prognosis. 14-3-3γ may be a novel and potential prognostic marker for breast cancer. |
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