A Multicenter,Randomized, Controlled Trial of Osteopathic Manipulative Treatment on Preterms |
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| Authors: | Francesco Cerritelli Gianfranco Pizzolorusso Cinzia Renzetti Vincenzo Cozzolino Marianna D’Orazio Mariacristina Lupacchini Benedetta Marinelli Alessandro Accorsi Chiara Lucci Jenny Lancellotti Silvia Ballabio Carola Castelli Daniela Molteni Roberto Besana Lucia Tubaldi Francesco Paolo Perri Paola Fusilli Carmine D’Incecco Gina Barlafante |
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| Affiliation: | 1. Clinical-based Human Research Department, Centre for Osteopathic Medicine—C.O.ME. Collaboration, Pescara, Italy.; 2. Accademia Italiana Osteopatia Tradizionale, Pescara, Italy.; 3. Neonatal Intensive Care Unit—Desio Public Hospital, Desio, Italy.; 4. Neonatal Intensive Care Unit—Macerata Public Hospital, Macerata, Italy.; 5. Neonatal Intensive Care Unit—Pescara Public Hospital, Pescara, Italy.; Seattle Childrens Hospital, UNITED STATES, |
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| Abstract: | BackgroundDespite some preliminary evidence, it is still largely unknown whether osteopathic manipulative treatment improves preterm clinical outcomes.ResultsA total of 695 newborns were randomly assigned to either the study group (n= 352) or the control group (n=343). A statistical significant difference was observed between the two groups for the primary outcome (13.8 and 17.5 days for the study and control group respectively, p<0.001, effect size: 0.31). Multivariate analysis showed a reduction of the length of stay of 3.9 days (95% CI -5.5 to -2.3, p<0.001). Furthermore, there were significant reductions with treatment as compared to usual care in cost (difference between study and control group: 1,586.01€; 95% CI 1,087.18 to 6,277.28; p<0.001) but not in daily weight gain. There were no complications associated to the intervention.ConclusionsOsteopathic treatment reduced significantly the number of days of hospitalization and is cost-effective on a large cohort of preterm infants. |
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