Toll-like receptors |
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Authors: | Muzio M Mantovani A |
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Institution: | Department of Immunology and Cell Biology, Mario Negri Institute, via Eritrea 62, 2015, Milan, Italy. |
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Abstract: | Toll-like receptors (TLRs) are a growing family of molecules involved in innate immunity. Accumulating evidence suggests that TLR molecules are involved in signalling receptor complexes which recognise components of Gram-positive and Gram-negative bacteria and mycobacteria. Differential expression and regulation as well as distinct though overlapping ligand recognition patterns may underlie the existence of a vast TLR family. Apparent structural and functional redundancy may render certain outputs of the TLR family robust. |
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