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Synthesis and antibacterial activity of novel neamine derivatives |
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| Authors: | Minowa Nobuto Akiyama Yoshihisa Hiraiwa Yukiko Maebashi Kazunori Usui Takayuki Ikeda Daishiro |
| Institution: | aPharmaceutical Research Department, Meiji Seika Kaisha, Ltd, 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan bMicrobial Chemistry Research Center, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan |
| Abstract: | Synthesis and activity of derivatives at the O5 or O6 positions of 1-N-((S)-4-amino-2-hydroxybutyryl)-3′,4′-dideoxyneamine, which is the neamine moiety of arbekacin, were reported. Among these results, the 5-O-aminoethylaminocarbonyl derivative showed effective activity against Staphylococcus aureus expressing a bifunctional aminoglycoside-modifying enzyme AAC(6′)-APH(2″). |
| Keywords: | Aminoglycoside Neamine Methicillin-resistant Staphylococcus aureus |
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