Mitochondrial contact sites as platforms for phospholipid exchange |
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Affiliation: | 1. Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, H166, Hershey, PA 17033, United States;2. Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, Texas Research Park, MC7755, 15355 Lambda Drive, San Antonio, TX 78245, United States;1. Institute of Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany;2. Center for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany |
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Abstract: | Mitochondria are unique organelles that contain their own – although strongly reduced – genome, and are surrounded by two membranes. While most cellular phospholipid biosynthesis takes place in the ER, mitochondria harbor the whole spectrum of glycerophospholipids common to biological membranes. Mitochondria also contribute to overall phospholipid biosynthesis in cells by producing phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. Considering these features, it is not surprising that mitochondria maintain highly active exchange of phospholipids with other cellular compartments. In this contribution we describe the transport of phospholipids between mitochondria and other organelles, and discuss recent developments in our understanding of the molecular functions of the protein complexes that mediate these processes. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum. |
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