| 改良CCI 大鼠痛行为学检测与损伤区自发放电活动再观察 |
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| 引用本文： | 巨文锋,薛莹,路美玲,张萌斌,李建宁.改良CCI 大鼠痛行为学检测与损伤区自发放电活动再观察[J].现代生物医学进展,2011,11(14):2632-2634. |
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| 作者姓名： | 巨文锋 薛莹 路美玲 张萌斌 李建宁 |
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| 作者单位： | 1. 陕西师范大学生命科学学院,陕西西安,710062
2. 陕西师范大学生命科学学院,陕西西安710062;宁夏医科大学基础医学院生物化学与分子生物学系,宁夏银川750004 |
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| 基金项目： | 国家自然科学基金项目(10772101,30770701,30900443); 国家高技术研究和发展项目(863)(2007AA02Z310) |
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| 摘 要： | 目的:应用改良CCI模型研究外周神经损伤后痛觉过敏和自发放电各自特征及相互关系.方法:雄性SD大鼠,随机分为CCI组和Sham组,分别于术前1天和术后1、4、7、9、11、14天测定机械刺激缩足反射阈值和热缩腿反射潜伏期,同时选取术侧机械刺激缩腿反射阈值低于4g或者术侧和健侧热缩腿反射潜伏期差异大于2s的CCI模型大鼠观察术后4-14天损伤区自发放电活动.结果:神经纤维损伤后,机械痛敏和热痛敏随时间表现为逐渐增强,同时在损伤区观察到三类放电模式:整数倍放电阵发放电和周期放电.结论:术后大鼠机械痛阈和热痛阈逐渐降低,机械痛敏的产生和损伤区自发放电活动关系密切,不同的放电模式可能代表不同的传入信息.
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| 关 键 词： | 改良CCI模型 机械痛敏 热痛敏 自发放电 |
Pain Behaviour and Ectopic Spontaneous Discharge in Modified Chronic
Constriction Injury Rats |
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| JU Wen-feng,XUE-ying,LU Mei-ling,ZHANG Meng-bin,LI Jian-ning.Pain Behaviour and Ectopic Spontaneous Discharge in Modified Chronic
Constriction Injury Rats[J].Progress in Modern Biomedicine,2011,11(14):2632-2634. |
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| Authors: | JU Wen-feng XUE-ying LU Mei-ling ZHANG Meng-bin LI Jian-ning |
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| Institution: | JU Wen-feng1,XUE-ying1,LU Mei-ling1,ZHANG Meng-bin1,LI Jian-ning1,2(1 College of Life Science,Shaanxi Normal University,710062,Xi'an,China,2 Department of Biochemistry,Basic College of Ningxia Medical University,750004,Yinchuan,China) |
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| Abstract: | To investigate characteristic and the relationship of the hyperalgesia and spontaneous discharges in modi-fied CCI rat.Methods: Male adult SD rats were randomly divided into experiment group(CCI) and control group(Sham).The mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL)were detected before operation and on 1d,4d,7d,9d,11d,14d after op-eration.The rats with MWT less than 4 g or with a TWL the difference of which was higher than 2 s between ipsilateral and contralateral hind paws wer... |
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| Keywords: | Modified Chronic constriction injury model Mechanical sensitivity Thermal sensitivity Spontaneous discharges |
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