射血分数正常性心力衰竭的预后研究--- 附三年随访结果分析

目的:评价射血分数(EF)正常性心力衰竭患者的流行病学特点及其3年预后,并与EF降低性心力衰竭患者进行比较.方法:选择2005-1至2006-12二所三甲医院心内科收治的461例慢性心衰患者,根据入院时左室EF分为EF正常组(EF＞=50%)和EF降低组(EF＜50%),进行为期3年的电话随访;终点事件包括全因死亡、心衰加重再住院.结果:慢性心衰患者中EF正常234例(50.7%),与EF下降患者比较,这类患者中较为高龄、多为女性;病因多为瓣膜病、高血压病及房颤;随访结果显示二组患者的终点事件发生率并无明显差异(P=0.578),Cox回归分析对其它因素校正后发现,房颤(RR=1.301,95%CI:0.995-1.701,P＜0.05)、年龄(RR=1.012,95%CI:1.003-1.022,P＜0.05)是影响慢性心衰患者3年预后的主要因素.结论:在慢性心衰中,EF正常的患者预后与EF下降者相似,对这类病人同样应加强监测及治疗.

Research of Prognosis of Chronic Heart Failure with Preserved Ejection Fraction

Objective: To evaluate the epidemiologic features and prognosis of patients with chronic heart failure(CHF) with pre-served ejection fraction(EF) and to compare with the patients who had CHF with reduced EF.Methods: From January,2005 to Decem-ber,2006 we studied 461 patients with a discharge diagnosis of CHF.Patients were devided by baseline EF in preserved EF(EF>=50%) and reduced EF(EF<50%) group.The main endpoints were all cause death within 3 years and readmission to the hospital for heart failure.Result...