Absence of suppression in natural and induced tolerance to F antigen |
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Authors: | Nance Beyer Nardi |
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Affiliation: | (1) ICRF Tumour Immunology Unit, Department of Zoology, University College London, Gower Street, WC1E 6BT London, England;(2) Present address: Disciplina de Genetica, FCM, Rua Sarmento Leite, 245 Porto Alegre, Brazil |
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Abstract: | ![]() The role of suppression in natural and induced tolerance to F antigen was investigated in two sets of experiments. In the first, CBA mice were submitted to pretreatments which decrease suppression and the antibody response to self- or allo-F type was investigated. The second set of experiments involved the transfer of spleen cells from tolerized or from naturally tolerant mice into normal mice which were then primed with allo-F, as well as the co-transfer of tolerant and primed lymphocytes into normal mice, to test whether tolerant lymphocytes present suppressor cells. The results indicate that the immune response against allo-F antigen is normally kept in a low level by a suppressive mechanism, and that F-specific suppressor T cells are absent from tolerant mice.Abbreviations used in this paper ATx adult thymectomy - BSS buffered salt solution - CFA Freund's complete adjuvant - CY cyclophosphamide - F.1 type-1 F antigen - F.2 type-2 F antigen - PBS phosphate-buffered saline - RIA radioimmunoassay - Th T helper cell - Ts T suppressor cell |
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