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Effect of Atrial Natriuretic Peptide on Sodium-Glucose Cotransport in the Rat Small Intestine
Authors:L.V Gonzá  lez Bosc,P.A Elustondo,M.C Ortiz,N.A Vidal
Affiliation:

A Biología Celular e Histología, Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, UBA and PROSIVAD-CONICET. Junin 956 (1113), Buenos Aires, Argentina

Abstract:GonzÁLez Bosc, L. V., P. A. Elustondo, M. C. Ortiz and N. A. Vidal. Effect of atrial natriuretic peptide on sodium-glucose cotransport in the rat small intestine. Peptides 18(10) 1491–1495, 1997.—Atrial natriuretic peptide (ANP) decreases sodium absorption in small intestine of rats in vitro under sodium concentration-gradient conditions (SCG) and this effect may be mediated by the inhibition of the sodium/glucose cotransporter (SGLT). In order to assess this hypothesis, the effects of ANP, phloridzine (Phlz) and methylene blue (MB), added alone or together, using a voltage clamp technique in Ussing’s chamber with SCG were studied. ANP and Phlz significantly decreased potential difference and short circuit current. Effects of Phlz and ANP were not additive. The addition of MB alone did not affect ion transport, whereas it abolished ANP effects. These data suggest that ANP blocks the SGLT through mechanisms mediated by cGMP and/or NO.
Keywords:Atrial natriuretic peptide   Ion transport   Glucose/sodium cotransporter   Voltage clamp   Ussing’s chamber   Nitric oxide   Phloridzine   Methylene blue
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