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Effects of missense mutation on structure and function of photoreceptor
Authors:Balázs Leitgeb  Vladyslava Sokolova  Eberhard Sch?fer  András Viczián
Affiliation:1.Institute of Biophysics; Biological Research Centre; Hungarian Academy of Sciences; Szeged, Hungary;2.Institute of Plant Biology; Biological Research Centre; Hungarian Academy of Sciences; Szeged, Hungary;3.Biologie II/Institut für Botanik; University of Freiburg; Freiburg, Germany
Abstract:Phytochromes (PHYs) are photoreceptors of the red (R ~660  nm) and far-red (FR ~730 nm) light, and they control a wide range of responses affecting crucial aspects of plant life. There are five genes PHYA-PHYE encoding for phytochromes of different but overlapping function. One of these, PHYA has the unique function controlling specific responses in high irradiance far-red, as well as in very weak light. Appropriate PHYA functioning requires not only the photoreversibility of molecule but also the proper nuclear localization and degradation of receptor. Recently, we identified and described a mutant PHYA allele (phyA-5) in Arabidopsis thaliana, which showed reduced binding affinity to FHY1/FHL, the proteins regulating its nuclear transport, resulting in impaired nuclear localization and altered signaling under certain conditions. We present here a hypothesis to explain how the identified amino acid substitution may lead to structural changes manifested as altered signaling and phenotype displayed by the phyA-5 mutant.
Keywords:Arabidopsis   photoreceptor   photomorphogenesis   phytochrome A   nuclear import   FHY1   FHL   3D structure
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