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Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation
Authors:Takumi Satoh  Sachie Saitoh  Kunio Kosaka
Affiliation:a Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4-3-5, Morioka, Iwate 020-8551, Japan
b Research and Development Center, Nagase Co., Ltd., Kobe, Hyogo 651-2241, Japan
Abstract:
Keywords:ARE, antioxidant-responsive element   BSA, bovine serum albumin   CA, carnosic acid   DEM, diethylmalate   FA, fumaric acid   Dt-BHQ, 2,5-di-tert-butylhydroquinone   GSH, reduced glutathione   MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide   NEM, N-ethylmaleimide   NEPP, neurite outgrowth-promoting prostaglandin   PBS, Ca2+, Mg2+ (&minus  )-phosphate-buffered saline   PED, pro-electrophilic drug   S-DOSA, simple detection of oxidative stress by serum albumin   TBHQ, tert-butyl hydroquinone.
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