|
|||||
|
|
Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator |
|
| Authors: | Xuejuan Feng Jing Zhao Zhisheng Jiang Bin Geng |
| Affiliation: | a Institute of Cardiovascular Diseases, Nan Hua University, Hengyang 421001, China b Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China c Institute of Cardiovascular Research, First Hospital of Peking University, Xishiku Street 8, Xicheng District, Beijing 100034, China |
| Abstract: | Recent data suggested that endogenous hydrogen sulfide (H2S) contributes to the pathogenesis of diabetes. Here, we identified that cystathionine gamma lyase (CSE) was expressed in adipose tissue in rats and endogenously generated H2S. The CSE/H2S system exists in both rat adipocytes and pre-adipocytes. This system was up-regulated with aging, although a high level of glucose down-regulated the system in a concentration- and time-dependent manner. H2S inhibited the basal and insulin-stimulated glucose uptake of mature adipocytes, whereas administration of CSE inhibitors enhanced the glucose uptake of adipocytes. The PI3K but not KATP channel pathway is involved in the inhibitory effect of H2S on glucose uptake. Finally, in fructose-induced diabetes in rats, we confirmed the up-regulated CSE/H2S system in adipose tissue, which was negatively correlated with glucose uptake in this tissue. Our findings suggest that H2S might be a novel insulin resistance regulator. |
| Keywords: | Hydrogen sulfide Cystathionine gamma lyase Glucose uptake Adipose Insulin resistance |
| 本文献已被 ScienceDirect 等数据库收录！ | |