FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis |
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| Authors: | Tina?JaskollEmail author George?Abichaker Daniel?Witcher Frederic?G?Sala Saverio?Bellusci Mohammad?K?Hajihosseini Michael?Melnick |
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| Affiliation: | (1) Laboratory Developmental Genetics, University of Southern California, Los Angeles, CA, USA;(2) Department of Surgery, and Division of Developmental Biology, The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, CA, USA;(3) School of Biological Sciences, University of East Anglia (UEA), Norwich, Norfolk, UK |
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| Abstract: | Background Analyses of Fgf10 and Fgfr2b mutant mice, as well as human studies, suggest that FGF10/FGFR2b signaling may play an essential, nonredundant role during embryonic SMG development. To address this question, we have analyzed the SMG phenotype in Fgf10 and Fgfr2b heterozygous and null mutant mice. In addition, although previous studies suggest that the FGF10/FGFR2b and FGF8/FGFR2c signaling pathways are functionally interrelated, little is known about the functional relationship between these two pathways during SMG development. We have designed in vivo and in vitro experiments to address this question. |
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