Alterations in brain metabolism induced by chronic morphine treatment: NMR studies in rat CNS |
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| Authors: | Sharma Sushil K Yashpal Kiran Fundytus Marian E Sauriol Françoise Henry James L Coderre Terence J |
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| Institution: | (1) Department of Physiology, McGill University, Montreal, Quebec, Canada;(2) Department of Psychiatry, McGill University, Montreal, Quebec, Canada;(3) Department of Anesthesia, McGill University, Montreal, Quebec, Canada;(4) Department of Chemistry, McGill University, Montreal, Quebec, Canada;(5) Departments of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada |
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| Abstract: | High-resolution (500 MHz) multiresonance/multinuclear proton (1H) nuclear magnetic resonance (NMR) spectroscopy was used to detect metabolic changes and cellular injury in the rat brain stem and spinal cord following chronic morphine treatment. Compensatory changes were observed in glycine, glutamate, and inositols in the brain stem, but not the spinal cord, of chronic morphine-treated rats. In spinal cord, increases were detected in lactate and N-acetyl-aspartate (NAA), suggesting that there is anaerobic glycolysis, plasma membrane damage, and altered pH preferentially in the spinal cord of chronic morphine-treated rats. |
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| Keywords: | Opioids nuclear magnetic resonance spectroscopy withdrawal inositol |
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