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NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Authors:Maria B. Olsen  Gunn A. Hildrestrand  Katja Scheffler  Leif Erik Vinge  Katrine Alfsnes  Vuk Palibrk  Junbai Wang  Christine G. Neurauter  Luisa Luna  Jostein Johansen  Jonas D.S. Øgaard  Ingrid K. Ohm  Geir Slupphaug  Anna Kuśnierczyk  Arnt E. Fiane  Sverre-Henning Brorson  Lili Zhang  Lars Gullestad  Alexandra V. Finsen
Affiliation:1. Research Institute of Internal Medicine, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway;2. Department of Microbiology, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway;3. Department of Cardiology, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway;4. Department of Haematology, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway;5. Department of Cardiothoracic Surgery, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway;6. Department of Pathology, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway;7. Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway;8. Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway;9. Center for Heart Failure Research, University of Oslo, 0317 Oslo, Norway;10. K.G. Jebsen Inflammation Research Centre, University of Oslo, 0317 Oslo, Norway;11. Department of Nutrition, University of Oslo, 0317 Oslo, Norway;12. Proteomics and Metabolomics Core Facility–PROMEC, Norwegian University of Science and Technology, 7491 Trondheim, Norway;13. Bioinformatics Core Facility–BioCore , Norwegian University of Science and Technology, 7491 Trondheim, Norway;14. Department of Computer and Information Science, Norwegian University of Science and Technology, 7491 Trondheim, Norway;15. Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
Abstract:
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  • Keywords:NEIL3  DNA glycosylase  base excision repair  cardiac fibroblast  cardiac myofibroblast  myocardial infarction  epigenome  DNA methylation  cardiac rupture  extracellular matrix modulation
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