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Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques
Authors:Jelena Petrovic  Yeqiao Zhou  Maria Fasolino  Naomi Goldman  Gregory W. Schwartz  Maxwell R. Mumbach  Son C. Nguyen  Kelly S. Rome  Yogev Sela  Zachary Zapataro  Stephen C. Blacklow  Michael J. Kruhlak  Junwei Shi  Jon C. Aster  Eric F. Joyce  Shawn C. Little  Golnaz Vahedi  Warren S. Pear  Robert B. Faryabi
Affiliation:1. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;2. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;3. Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;4. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;5. Department of Genetics, Stanford University, Stanford, CA 94305, USA;6. Department of Biological Chemistry, Harvard Medical School, Boston, MA 02215, USA;7. Center for Cancer Research, NIH, Bethesda, MD 20892, USA;8. Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA;9. Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;10. Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;11. Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Abstract:
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  • Keywords:genome organization  gene regulation  oncogenic signaling  Notch  breast cancer  lymphoma
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