Measurement of urinary free cortisol by current immunoassays: need for sex-dependent reference ranges to define hypercortisolism |
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| Authors: | Deutschbein T Broecker-Preuss M Hartmann M F Althoff R Wudy S A Mann K Petersenn S |
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| Affiliation: | Department of Endocrinology and Division of Laboratory Research, University of Duisburg-Essen, Essen, Germany. |
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| Abstract: | Urinary free cortisol (UFC) is used to assess disease activity in hypercortisolemic patients. However, reference ranges are often lacking, especially with respect to potential confounding variables. This study analyzed upper limits of normal (ULN, mean?+?2?SD) for 2 newer immunoassays, using gas chromatography-mass spectrometry (GC-MS) as reference method. Each 10 healthy subjects were grouped by age (18-29; 30-49; ≥?50 years), BMI (
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