Gnetol as a potent tyrosinase inhibitor from genus Gnetum |
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| Authors: | Ohguchi Kenji Tanaka Toshiyuki Iliya Ibrahim Ito Tetsuro Iinuma Munekazu Matsumoto Kenji Akao Yukihiro Nozawa Yoshinori |
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| Affiliation: | Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan. kohguchi@giib.or.jp |
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| Abstract: | Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells. |
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