Plasmodium yoelii: distinct CD4(+)CD25(+) regulatory T cell responses during the early stages of infection in susceptible and resistant mice |
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Authors: | Wu Yi Wang Qing-hui Zheng Li Feng Hui Liu Jun Ma Shi-hong Cao Ya-ming |
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Institution: | Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, China. |
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Abstract: | The outcome of experimental murine infection with different strains of malaria parasites, ranging from spontaneous cure to death, depends largely on the establishment of effective Th1 responses during the early stages of infection. Here we describe the disparity in CD4(+)CD25(+) regulatory T cell (Treg) responses during the early stages of infection with the highly virulent Plasmodium yoelii 17XL strain in susceptible (BALB/c) and resistant (DBA/2) mice. An increased proportion of Tregs 3-4 days post inoculation, co-occurring with elevated IL-10 levels, is observed in BALB/c but not in DBA/2 mice. These findings suggest that Treg proliferation might be causally associated with the suppression of Th1 responses during early malaria infection, leading to increase parasitemia and mortality in BALB/c mice, possibly in an IL-10-dependent manner. |
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Keywords: | Plasmodium yoelii Immunoregulation ANOVA analysis of variance IFN-γ interferon gamma IL-10 interleukin-10 i p intraperitoneal NO nitric oxide p i post inoculation Py17XL lethal strain of Plasmodium yoelii 17X TGF-β transforming growth factor-beta Tregs CD4+CD25+ regulatory T cells |
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