| 细胞外基质力学性质对实体肿瘤血管生成影响的数值模拟 |
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| 引用本文： | Gulnara Kalkabay,曹金凤,蔡彦,许世雄.细胞外基质力学性质对实体肿瘤血管生成影响的数值模拟[J].上海生物医学工程,2008(3):131-135. |
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| 作者姓名： | Gulnara Kalkabay 曹金凤 蔡彦 许世雄 |
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| 作者单位： | 复旦大学力学与工程科学系; |
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| 基金项目： | 国家自然科学基金项目(10772751)(10372026);;上海市重点学科建设项目(B112) |
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| 摘 要： | 考虑细胞外基质ECM力学性质对实体肿瘤血管生成的影响，数值模拟肿瘤内外血管网络。将肿瘤外正常组织ECM和肿瘤组织ECM均设为线弹性体，考虑内皮细胞的扩散运动、对肿瘤血管生成因子TAF的趋化性响应、对粘连蛋白FIN趋触性响应以及对流运动，进行数值模拟。计算结果表明模型能够获得较为真实的分层毛细血管网络。
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| 关 键 词： | 实体肿瘤 血管数值生成 细胞外基质 力学性质 |
Numerical Simulation on the Effect of Mechanical Properties of ECM on Tumor-induced Angiogenesis |
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| Gulnara Kalkabay CAO Jin-feng CAI Yan XU Shi-xiong.Numerical Simulation on the Effect of Mechanical Properties of ECM on Tumor-induced Angiogenesis[J].Shanghai Journal of Biomedical Engineering,2008(3):131-135. |
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| Authors: | Gulnara Kalkabay CAO Jin-feng CAI Yan XU Shi-xiong |
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| Institution: | Shanghai 200433 |
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| Abstract: | In this paper,we investigate the effect of mechanical properties of ECM on tumor-induced an- giogenesis and simulate the capillary network numerically.The ECM is assumed to be linear elastic.Diffusible movement,chemotactic response to TAF,haptactic response to FN,and convection are considered in the model. The calculation results a layered structure:at the edge of tumor,numerous capillaries are generated,while closer to the tumor center,less the capillary. |
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| Keywords: | Solid Tumor Numerical angiogenic ECM Mechanical properties |
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