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Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties |
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| Authors: | Bruncko Milan McClellan William J Wendt Michael D Sauer Daryl R Geyer Andrew Dalton Christopher R Kaminski Michele A Weitzberg Moshe Gong Jane Dellaria Joseph F Mantei Robert Zhao Xumiao Nienaber Vicki L Stewart Kent Klinghofer Vered Bouska Jennifer Rockway Todd W Giranda Vincent L |
| Affiliation: | Cancer Research, Global Pharmaceutical R&D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA. milan.bruncko@abbott.com |
| Abstract: |  A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors. |
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