Dietary modulation of DNA damage in human |
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Authors: | Michael G Simic David S Bergtold |
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Institution: | National Institute of Standards and Technology, Gaithersburg, MD 20899, U.S.A. |
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Abstract: | Manipulation of human diet can modulate urinary biomarkers of oxidative DNA base damage (UBODBD), reflecting changes in levels of DNA damage. When dietary composition is maintained but caloric intake is decreased (caloric restriction), UBODBD excretion is suppressed. At isocaloric dietary intake the level of damage depends on diet composition. For diets consisting of foods containing carbohydrates, proteins, and fats but lacking fruits and vegetables, the level of damage is higher than for diets including fruits and vegetables, which are rich in natural antioxidants. Assay of urinary biomarkers is suggested as a potential test for quantitative assessment of the carcinogenic or anticarcinogenic properties of foods, food components, and diets and for individual responses to nutritional regimens. |
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Keywords: | Aging Antioxidants Biomarkers Caloric restriction Diet DNA damage Hydroxyl radical Oxidative processes Prevention of degenerative diseases Reactive oxygen species |
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