| E3B1在肿瘤中的作用及其机制 |
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| 引用本文： | 卞士柱,陈彬,马进举.E3B1在肿瘤中的作用及其机制[J].生命的化学,2011(1). |
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| 作者姓名： | 卞士柱 陈彬 马进举 |
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| 作者单位： | 第三军医大学学员旅1队;第三军医大学生物化学与分子生物学教研室; |
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| 基金项目： | 国家自然科学基金(30972933); 重庆市自然科学基金(CSTC.2009AC5173); 第三军医大学归国人员启动基金(2009)资助 |
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| 摘 要： | EPS8的结合蛋白质E3B1具有广泛的生物学功能,参与细胞骨架的重塑、生长因子受体(GFR)介导的细胞应答,抑制细胞生长,并通过E3B1-EPS8-SOS1三联复合物参与Ras到Rac细胞信号转导,这些功能使得E3B1及其家族蛋白质具有潜在的肿瘤抑制作用,与肿瘤的发生、发展密切相关。目前对于E3B1的研究主要集中在其信号通路,对于E3B1在肿瘤中的作用及其机制的研究有待于进一步加强,这些研究可能为肿瘤的转移途径、转化方式的研究提供重要的理论线索。
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| 关 键 词： | E3B1 Rac Ras 肿瘤 |
The function of E3B1 in tumors and its mechanisms |
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| BIAN Shizhu,CHEN Bin,MA Jinju.The function of E3B1 in tumors and its mechanisms[J].Chemistry of Life,2011(1). |
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| Authors: | BIAN Shizhu CHEN Bin MA Jinju |
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| Institution: | BIAN Shizhu2,CHEN Bin1,MA Jinju2 1Department of Biochemistry and Molecular Biology,Third Military Medical University,Chongqing 400038,China,2Squadron 1 of Cadet Brigade,Third Military Melitary Medical University |
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| Abstract: | E3B1, an EPS8 binding protein, has a variety of biologic functions. It is involved in cytoskeleton remodeling, GFR-mediated cellular response and cell growth inhibition. In the form of E3B1-EPS8-SOS1 complex, E3B1 also plays an important role in Ras to Rac cell signaling. These functions endow E3B1 and its familial proteins with a potential role for inhibiting tumor, and make them closely related to tumorigenesis and tumor development. Presently, studies on E3B1 are mainly focused on its signaling pathway. ... |
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| Keywords: | E3B1 Rac Ras tumor |
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